Granada Lab

Publications

For a complete and up-to-date list of all publications and citation metrics, please visit Adrián Granada’s Google Scholar profile.

Since starting our research group in 2020

  1. Circadian rhythm heterogeneity modulates drug response variations in neuroblastoma models

    Carolin Ector, Christoph Schmal, Jeff Didier, Achim Kramer, Hanspeter Herzel, Adrián E. Granada

    Cell Reports (2026) 45

    Article

    Graphical abstract

  2. Circadian coupling orchestrates cell growth

    Nica Gutu, Malthe S. Nordentoft, Marlena Kuhn, Carolin Ector, Marie Möser, Anna-Marie Finger, Mathias Spliid Heltberg, Mogens Høgh Jensen, Ulrich Keilholz, Achim Kramer, Hanspeter Herzel, Adrián E. Granada

    Nature Physics (2025)

    ArticleNature Physics News & Views

    Figure from the article

  3. Circadian clock features define novel subtypes among breast cancer cells and shape drug sensitivity

    Carolin Ector, Jeff Didier, Sébastien De Landtsheer, Malthe S. Nordentoft, Christoph Schmal, Ulrich Keilholz, Hanspeter Herzel, Achim Kramer, Thomas Sauter, Adrián E. Granada

    Molecular Systems Biology (2025) · Featured on the cover

    Article

    Journal cover

  4. A combined mathematical and experimental approach reveals the drivers of time-of-day drug sensitivity in human cells

    Nica Gutu, Carolin Ector, Ulrich Keilholz, Hanspeter Herzel, Adrián E. Granada

    Communications Biology (2025)

    Article

  5. Onkologische Therapien am besten zur individuell optimalen Tageszeit

    Carolin Ector & Adrián E. Granada

    Deutsches Ärzteblatt (2025) · Perspektiven der Onkologie · Featured on the cover

    Article

    Journal cover

  6. Time-of-day effects of drugs revealed by high-throughput deep phenotyping

    Carolin Ector, Christoph Schmal, Jeff Didier, Sébastien De Landtsheer, Anna-Marie Finger, Francesca Müller-Marquardt, Johannes Schulte, Thomas Sauter, Ulrich Keilholz, Hanspeter Herzel, Achim Kramer, Adrián E. Granada

    Nature Communications (2024)

    Article

    News articles about our work

  7. Circadian period is compensated for repressor protein turnover rates in single cells

    Christian H. Gabriel, Marta Del Olmo, Arunya Rizki Widini, Rashin Roshanbin, Jonas Woyde, Ebrahim Hamza, Nica-Nicoleta Gutu, Amin Zehtabian, Helge Ewers, Adrián E. Granada, Hanspeter Herzel, Achim Kramer

    PNAS – Proceedings of the National Academy of Sciences (2024)

    Article

  8. Circadian coupling orchestrates cell growth

    Nica Nicoleta Gutu, Malthe Nordentoft, Marlena Kuhn, Carolin Ector, Anna Marie Finger, Mathias Spliid Heltberg, Mogens Høgh Jensen, Ulrich Keilholz, Achim Kramer, Hanspeter Herzel, Adrián E. Granada

    Preprint, bioRxiv (2024)

    Preprint

  9. Time-of-day effects of drugs revealed by high-throughput deep phenotyping

    Carolin Ector, Christoph Schmal, Jeff Didier, Sébastien De Landtsheer, Anna-Marie Finger, Francesca Müller-Marquardt, Johannes Schulte, Thomas Sauter, Ulrich Keilholz, Hanspeter Herzel, Achim Kramer, Adrián E. Granada

    Preprint, bioRxiv (2024)

    Preprint

  10. p53 and p21 dynamics encode single-cell DNA damage levels, fine-tuning proliferation and shaping population heterogeneity

    Nica Gutu, Neha Binish, Ulrich Keilholz, Hanspeter Herzel, Adrián E. Granada

    Communications Biology 6, 1196 (2023)

    Article

  11. Analysis of complex circadian time series data using wavelets

    Christoph Schmal, Gregor Mönke, Adrián E. Granada

    Circadian Regulation: Methods and Protocols, 35–54 (2022)

    Chapter

  12. Intercellular coupling between peripheral circadian oscillators by TGF-β signaling

    Anna-Marie Finger, Sebastian Jäschke, Marta Del Olmo, Robert Hurwitz, Adrián E. Granada, Hanspeter Herzel, Achim Kramer

    Science Advances 7(30), eabg5174 (2021)

    Article

  13. Live-cell imaging of circadian clock protein dynamics in CRISPR-generated knock-in cells

    Christian H. Gabriel, Marta Del Olmo, Amin Zehtabian, Marten Jäger, Silke Reischl, Hannah van Dijk, Carolin Ulbricht, Asylkhan Rakhymzhan, Thomas Korte, Barbara Koller, Astrid Grudziecki, Bert Maier, Andreas Herrmann, Raluca Niesner, Tomasz Zemojtel, Helge Ewers, Adrián E. Granada, Hanspeter Herzel, Achim Kramer

    Nature Communications 12(1), 3796 (2021)

    Article

  14. Optimal time frequency analysis for biological data – pyBOAT

    Gregor Mönke, Frieda A. Sorgenfrei, Christoph Schmal, Adrián E. Granada

    Preprint, bioRxiv (2020)

    PreprintpyBOAT software repository

  15. The effects of proliferation status and cell cycle phase on the responses of single cells to chemotherapy

    Adrián E. Granada, Alba Jiménez, Jacob Stewart-Ornstein, Nils Blüthgen, Simone Reber, Ashwini Jambhekar, Galit Lahav

    Molecular Biology of the Cell 31(8) (2020)

    Article

Before the Granada Lab (prior to 2020)

  1. Information transfer in the mammalian circadian clock

    Granada AE, Herzel H, Kramer A, Abraham U

    Information- and Communication Theory in Molecular Biology, Lecture Notes in Bioengineering. Springer (2018)

    Chapter

  2. Tuning the phase of circadian entrainment

    Bordyugov G, Abraham U, Granada AE, Rose P, Imkeller K, Kramer A, Herzel H

    Journal of the Royal Society Interface 12(108) (2015)

    Article

  3. Genetic redundancy strengthens the circadian clock leading to a narrow entrainment range

    Erzberger A, Hampp G, Granada AE, Albrecht U, Herzel H

    Journal of the Royal Society Interface 10(84):20130221 (2013)

    Article

  4. Human chronotypes from a theoretical perspective

    Granada AE, Bordyugov G, Kramer A, Herzel H

    PLoS One 8(3):e59464 (2013)

    Article

  5. How coupling determines the entrainment of circadian clocks

    Bordyugov G*, Granada AE*, Herzel H

    European Physical Journal B (2011)

  6. Circadian desynchronization

    Granada AE, Cambras T, Díez-Noguera A, Herzel H

    Interface Focus 1:153–166 (2011)

    Article

  7. Transients and bifurcations of the mammalian circadian system: from synchronization to desynchronization mechanisms

    Granada AE

    Logos-Verlag (2011) · ISBN-13: 978-3-8325-2966-6

    Book

  8. Coupling governs entrainment range of circadian clocks

    Abraham U*, Granada AE*, Westermark PO*, Heine M*, Kramer A, Herzel H

    Molecular Systems Biology 6:438 (2010)

    Article

  9. How to achieve fast entrainment? The timescale to synchronization

    Granada AE, Herzel H

    PLoS One 4:e7057 (2009)

    Article

  10. Phase response curves elucidating the dynamics of coupled oscillators

    Granada AE, Hennig RM, Ronacher B, Kramer A, Herzel H

    Methods in Enzymology 454:1–27 (2009)

    Article

  11. The generation of respiratory rhythms in birds

    Granada AE, Gabitto M, García G, Alliende J, Méndez J, Trevisan M, Mindlin GB

    Physica A 371:84–87 (2006)

    Article