Publications

Understanding cell fate decisions with temporal attention

Florian Bürger, Martim Dias Gomes, Adrián E. Granada, Noémie Moreau, Katarzyna Bozek

PLOS Computational Biology (accepted) · arXiv:2603.16562 · 2026

Accepted 2026

Circadian rhythm heterogeneity modulates drug response variations in neuroblastoma models

Carolin Ector, Christoph Schmal, Jeff Didier, Sébastien De Landtsheer, Johannes H. Schulte, Ulrich Keilholz, Thomas Sauter, Achim Kramer, Hanspeter Herzel, Adrián E. Granada

Cell Reports 45, 116975 · 2026 · doi:10.1016/j.celrep.2026.116975

Last author

TransientTrack: advanced multi-object tracking and classification of cancer cells with transient fluorescent signals

Florian Bürger, Martim Dias Gomes, Nica Gutu, Adrián E. Granada, Noémie Moreau, Katarzyna Bozek

arXiv (preprint) 2512.01885 · 2025

Multi-drug pharmacotyping improves therapy prediction in pancreatic cancer organoids

Katharina Wansch, Uwe Pelzer, François Schneider, Florian Dölvers, Anna Kühn, Mihnea P. Dragomir, Jana Ihlow, Georg Hilfenhaus, Loredana Vecchione, Matthäus Felsenstein, Dou Ma, Markus Lerchbaumer, Christian Jürgensen, Marcus Bahra, Adrián E. Granada, Gregor Duwe, Sebastian Stintzing, Ulrich Keilholz, Christopher C. M. Neumann

Cancer Cell International 25, 321 · 2025 · doi:10.1186/s12935-025-03969-7

Inheritable cell-states shape drug-persister correlations and population dynamics in cancer cells

Anton Iyer, Adrian Alva, Adrián E. Granada, Shaon Chakrabarti

PLOS Computational Biology 21, e1013446 · 2025 · doi:10.1371/journal.pcbi.1013446

Onkologische Therapien am besten zur individuell optimalen Tageszeit

Carolin Ector, Adrián E. Granada

Deutsches Ärzteblatt · Perspektiven der Onkologie · 2025

Last authorFeatured on the cover

Circadian coupling orchestrates cell growth

Nica Gutu, Malthe S. Nordentoft, Marlena Kuhn, Carolin Ector, Marie Möser, Anna-Marie Finger, Mathias Spliid Heltberg, Mogens Høgh Jensen, Ulrich Keilholz, Achim Kramer, Hanspeter Herzel, Adrián E. Granada

Nature Physics 21, 768–777 · 2025 · doi:10.1038/s41567-025-02838-4

Last author

Reveal more

Nature Physics News & Views

A combined mathematical and experimental approach reveals the drivers of time-of-day drug sensitivity in human cells

Nica Gutu, Hitoshi Ishikuma, Carolin Ector, Ulrich Keilholz, Hanspeter Herzel, Adrián E. Granada

Communications Biology 8, 491 · 2025 · doi:10.1038/s42003-025-07931-1

Last author

Circadian clock features define novel subtypes among breast cancer cells and shape drug sensitivity

Carolin Ector, Jeff Didier, Sébastien De Landtsheer, Malthe S. Nordentoft, Christoph Schmal, Ulrich Keilholz, Hanspeter Herzel, Achim Kramer, Thomas Sauter, Adrián E. Granada

Molecular Systems Biology 21(4), 315–340 · 2025 · doi:10.1038/s44320-025-00092-7

Last authorFeatured on the cover

Time-of-day effects of cancer drugs revealed by high-throughput deep phenotyping

Carolin Ector, Christoph Schmal, Jeff Didier, Sébastien De Landtsheer, Anna-Marie Finger, Francesca Müller-Marquardt, Johannes H. Schulte, Thomas Sauter, Ulrich Keilholz, Hanspeter Herzel, Achim Kramer, Adrián E. Granada

Nature Communications 15, 7205 · 2024 · doi:10.1038/s41467-024-51611-3

Last author

Reveal more

Circadian period is compensated for repressor protein turnover rates in single cells

Christian H. Gabriel, Marta Del Olmo, Arunya Rizki Widini, Rashin Roshanbin, Jonas Woyde, Ebrahim Hamza, Nica-Nicoleta Gutu, Amin Zehtabian, Helge Ewers, Adrián E. Granada, Hanspeter Herzel, Achim Kramer

PNAS · 2024 · doi:10.1073/pnas.2404738121

Circadian coupling orchestrates cell growth (preprint)

Nica Nicoleta Gutu, Malthe Nordentoft, Marlena Kuhn, Carolin Ector, Anna Marie Finger, Mathias Spliid Heltberg, Mogens Høgh Jensen, Ulrich Keilholz, Achim Kramer, Hanspeter Herzel, Adrián E. Granada

bioRxiv (preprint) · 2024 · doi:10.1101/2024.05.18.594797

Last author

Time-of-day effects of drugs revealed by high-throughput deep phenotyping (preprint)

Carolin Ector, Christoph Schmal, Jeff Didier, Sébastien De Landtsheer, Anna-Marie Finger, Francesca Müller-Marquardt, Johannes Schulte, Thomas Sauter, Ulrich Keilholz, Hanspeter Herzel, Achim Kramer, Adrián E. Granada

bioRxiv (preprint) · 2023 · doi:10.1101/2023.11.30.569380

Last author

p53 and p21 dynamics encode single-cell DNA damage levels, fine-tuning proliferation and shaping population heterogeneity

Nica Gutu, Neha Binish, Ulrich Keilholz, Hanspeter Herzel, Adrián E. Granada

Communications Biology 6, 1196 · 2023 · doi:10.1038/s42003-023-05585-5

Last author

Analysis of complex circadian time series data using wavelets

Christoph Schmal, Gregor Mönke, Adrián E. Granada

Circadian Regulation: Methods and Protocols (Methods in Molecular Biology), 35–54 · 2022 · doi:10.1007/978-1-0716-2249-0_3

Last author

Intercellular coupling between peripheral circadian oscillators by TGF-β signaling

Anna-Marie Finger, Sebastian Jäschke, Marta Del Olmo, Robert Hurwitz, Adrián E. Granada, Hanspeter Herzel, Achim Kramer

Science Advances 7(30), eabg5174 · 2021 · doi:10.1126/sciadv.abg5174

Live-cell imaging of circadian clock protein dynamics in CRISPR-generated knock-in cells

Christian H. Gabriel, Marta Del Olmo, Amin Zehtabian, Marten Jäger, Silke Reischl, Hannah van Dijk, Carolin Ulbricht, Asylkhan Rakhymzhan, Thomas Korte, Barbara Koller, Astrid Grudziecki, Bert Maier, Andreas Herrmann, Raluca Niesner, Tomasz Zemojtel, Helge Ewers, Adrián E. Granada, Hanspeter Herzel, Achim Kramer

Nature Communications 12(1), 3796 · 2021 · doi:10.1038/s41467-021-24086-9

Optimal time frequency analysis for biological data – pyBOAT

Gregor Mönke, Frieda A. Sorgenfrei, Christoph Schmal, Adrián E. Granada

bioRxiv (preprint) · 2020 · doi:10.1101/2020.04.29.067744

Last author

Reveal more

pyBOAT software repository

The effects of proliferation status and cell cycle phase on the responses of single cells to chemotherapy

Adrián E. Granada, Alba Jiménez, Jacob Stewart-Ornstein, Nils Blüthgen, Simone Reber, Ashwini Jambhekar, Galit Lahav

Molecular Biology of the Cell 31(8), 845–857 · 2020 · doi:10.1091/mbc.E19-09-0515

First author

Information transfer in the mammalian circadian clock

Granada AE, Herzel H, Kramer A, Abraham U

Information- and Communication Theory in Molecular Biology (Lecture Notes in Bioengineering), Springer · 2018 · doi:10.1007/978-3-319-54729-9_11

First author

How coupling determines the entrainment of circadian clocks

Bordyugov G*, Granada AE*, Herzel H

European Physical Journal B 82(3), 227–234 · 2011

Shared first author

Circadian desynchronization

Granada AE, Cambras T, Díez-Noguera A, Herzel H

Interface Focus 1, 153–166 · 2011 · doi:10.1098/rsfs.2010.0002

First author

Transients and bifurcations of the mammalian circadian system: from synchronization to desynchronization mechanisms

Granada AE

Logos-Verlag · ISBN 978-3-8325-2966-6 · 2011

Sole author

Coupling governs entrainment range of circadian clocks

Abraham U*, Granada AE*, Westermark PO*, Heine M*, Kramer A, Herzel H

Molecular Systems Biology 6, 438 · 2010 · doi:10.1038/msb.2010.92

Shared first author

How to achieve fast entrainment? The timescale to synchronization

Granada AE, Herzel H

PLoS One 4, e7057 · 2009 · doi:10.1371/journal.pone.0007057

First author

Phase response curves elucidating the dynamics of coupled oscillators

Granada AE, Hennig RM, Ronacher B, Kramer A, Herzel H

Methods in Enzymology 454, 1–27 · 2009

First author

The generation of respiratory rhythms in birds

Granada AE, Gabitto M, García G, Alliende J, Méndez J, Trevisan M, Mindlin GB

Physica A 371, 84–87 · 2006

First author

Understanding cell fate decisions with temporal attention

Circadian rhythm heterogeneity modulates drug response variations in neuroblastoma models

TransientTrack: advanced multi-object tracking and classification of cancer cells with transient fluorescent signals

Multi-drug pharmacotyping improves therapy prediction in pancreatic cancer organoids

Inheritable cell-states shape drug-persister correlations and population dynamics in cancer cells

Onkologische Therapien am besten zur individuell optimalen Tageszeit

Circadian coupling orchestrates cell growth

A combined mathematical and experimental approach reveals the drivers of time-of-day drug sensitivity in human cells

Circadian clock features define novel subtypes among breast cancer cells and shape drug sensitivity

Time-of-day effects of cancer drugs revealed by high-throughput deep phenotyping

Circadian period is compensated for repressor protein turnover rates in single cells

Circadian coupling orchestrates cell growth (preprint)

Time-of-day effects of drugs revealed by high-throughput deep phenotyping (preprint)

p53 and p21 dynamics encode single-cell DNA damage levels, fine-tuning proliferation and shaping population heterogeneity

Analysis of complex circadian time series data using wavelets

Intercellular coupling between peripheral circadian oscillators by TGF-β signaling

Live-cell imaging of circadian clock protein dynamics in CRISPR-generated knock-in cells

Optimal time frequency analysis for biological data – pyBOAT

The effects of proliferation status and cell cycle phase on the responses of single cells to chemotherapy

Information transfer in the mammalian circadian clock

Tuning the phase of circadian entrainment

Genetic redundancy strengthens the circadian clock leading to a narrow entrainment range

Human chronotypes from a theoretical perspective

How coupling determines the entrainment of circadian clocks

Circadian desynchronization

Transients and bifurcations of the mammalian circadian system: from synchronization to desynchronization mechanisms

Coupling governs entrainment range of circadian clocks

How to achieve fast entrainment? The timescale to synchronization

Phase response curves elucidating the dynamics of coupled oscillators

The generation of respiratory rhythms in birds