publications

 

Publications Since Starting our Research Group in 2020

 

Time-of-day effects of drugs revealed by high-throughput deep phenotyping

Carolin Ector, Christoph Schmal, Jeff Didier, Sébastien De Landtsheer, Anna-Marie Finger, Francesca Müller-Marquardt, Johannes Schulte, Thomas Sauter, Ulrich Keilholz, Hanspeter Herzel, Achim Kramer, Adrián E. Granada

Nature Communications (2024). Link

 
News articles about our work

Charite Press Release
Eurekalert

Inside Precision Medicine

Aljazeera
Ma Clinique
Pharmazeutische Zeitung

More articles here

 

Circadian period is compensated for repressor protein turnover rates in single cells

Christian H Gabriel, Marta Del Olmo, Arunya Rizki Widini, Rashin Roshanbin, Jonas Woyde, Ebrahim Hamza, Nica-Nicoleta Gutu, Amin Zehtabian, Helge Ewers, Adrian Granada, Hanspeter Herzel, Achim Kramer

PNAS | Proceedings of the National Academy of Sciences(2024). Link

 

Circadian Coupling Orchestrates Cell Growth

Nica Nicoleta Gutu, Malthe Nordentoft, Marlena Kuhn, Carolin Ector, Anna Marie Finger, Mathias Spliid Heltberg, Mogens Hogh Jensen, Ulrich Keilholz, Achim Kramer, Hanspeter Herzel, Adrian E. Granada

Preprint Biorxiv (2024). Link

Time-of-day effects of drugs revealed by high-throughput deep phenotyping

Carolin Ector, Christoph Schmal, Jeff Didier, Sébastien De Landtsheer, Anna-Marie Finger, Francesca Müller-Marquardt, Johannes Schulte, Thomas Sauter, Ulrich Keilholz, Hanspeter Herzel, Achim Kramer, Adrián E. Granada

Preprint Biorxiv (2024). Link

p53 and p21 dynamics encode single cell DNA damage levels, fine-tuning proliferation and shaping population’s heterogeneity

Nica Gutu, Neha Binish, Ulrich Keilholz, Hanspeter Herzel, Adrián E. Granada

Communications Biology Vol. 6, 1196 (2023). Link

Analysis of complex circadian time series data using wavelets

Christoph Schmal, Gregor Mönke, Adrián E Granada.

Circadian Regulation: Methods and Protocols, 35-54, (2022). Link

Intercellular coupling between peripheral circadian oscillators by TGF-β signaling

Anna-Marie Finger, Sebastian Jäschke, Marta Del Olmo, Robert Hurwitz, Adrián E Granada, Hanspeter Herzel, Achim Kramer

Science advances 7 (30), eabg5174, (2021). Link

Live-cell imaging of circadian clock protein dynamics in CRISPR-generated knock-in cells

Christian H Gabriel, Marta Del Olmo, Amin Zehtabian, Marten Jäger, Silke Reischl, Hannah van Dijk, Carolin Ulbricht, Asylkhan Rakhymzhan, Thomas Korte, Barbara Koller, Astrid Grudziecki, Bert Maier, Andreas Herrmann, Raluca Niesner, Tomasz Zemojtel, Helge Ewers, Adrián E Granada, Hanspeter Herzel, Achim Kramer

Nature communications 12 (1), 3796, (2021). Link

Optimal time frequency analysis for biological data – pyBOAT.

Gregor Mönke, Frieda A. Sorgenfrei, Christoph Schmal, Adrián E. Granada.

Preprint biorXiv doi.org/10.1101/2020.04.29.067744 (2020). Link

PyBOAT software repository

The effects of proliferation status and cell cycle phase on the responses of single cells to chemotherapy.

Adrián E. Granada, Alba Jiménez, Jacob Stewart-Ornstein, Nils Blüthgen, Simone Reber, Ashwini Jambhekar, and Galit Lahav.

Molecular Biology of the Cell . Volume 31, Issue 8. (2020). Link


Publications Prior to the Start of the Granada Lab Research Group in 2020


Information Transfer in the Mammalian Circadian Clock.

Granada AE, Herzel H, Kramer A, Abraham U.

Information and Communication Theory in Molecular Biology. Springer (2018). Link

Tuning the phase of circadian entrainment.

Bordyugov G, Abraham U, Granada AE, Rose P, Imkeller K, Kramer A, Herzel H

Journal of the Royal Society Interface. 6;12(108), (2015).  Link

Genetic redundancy strengthens the circadian clock leading to a narrow entrainment range

Erzberger A, Hampp G, Granada AE, Albrecht U, Herzel H.

Journal of the Royal Society Interface 10(84):20130221, (2013). Link

Human chronotypes from a theoretical perspective

Granada AE, Bordyugov G, Kramer A, Herzel H .

PLoS One 8(3):e59464, (2013). Link

How Coupling Determines the Entrainment of Circadian Clocks.

Bordyugov G*, Granada AE*, and Herzel H.

European Physical Journal B, (2011). Link

Circadian desynchronization.

Granada AE, Cambras T, Diez-Noguera A, Herzel H.

Journal of the Royal Society Interface 1:153-166, (2011). Link

Transients and bifurcations of the mammalian circadian system: From synchronization to desynchronization mechanisms

Granada AE.

Logos-Verlag. ISBN-13:  978-3-8325-2966-6, (2011). Link

Coupling governs entrainment range of circadian clocks.

Abraham U*, Granada AE*, Westermark PO*, Heine M*, Kramer A, and Herzel H

Molecular Systems Biology, 6:438, (2010). Link

How to achieve fast entrainment? The timescale to synchronization.

Granada AE, Herzel H (2009)

PLoS One 4: e7057, (2009). Link

Phase response curves elucidating the dynamics of coupled oscillators.

Granada AE, Hennig RM, Ronacher B, Kramer A, Herzel H

Methods in Enzymology 454:1–27, (2009). Link

The generation of respiratory rhythms in birds

Granada AE, Gabitto M, García G, Alliende J, Méndez J, Trevisan M, Mindlin GB.

Physica A. 371:84–87, (2006). Link