publications
Publications Since Starting our Research Group in 2020
Circadian coupling orchestrates cell growth
Nica Gutu, Malthe S. Nordentoft, Marlena Kuhn, Carolin Ector , Marie Möser, Anna-Marie Finger, Mathias Spliid Heltberg, Mogens Høgh Jensen, Ulrich Keilholz, Achim Kramer, Hanspeter Herzel, Adrián E. Granada.
Nature Physics (2025).
Circadian clock features define novel subtypes among breast cancer cells and shape drug sensitivity
Carolin Ector, Jeff Didier, Sébastien De Landtsheer, Malthe S Nordentoft, Christoph Schmal, Ulrich Keilholz, Hanspeter Herzel, Achim Kramer,
Thomas Sauter, Adrián E Granada
Molecular Systems Biology (2025).
Onkologische Therapien am besten zur individuell optimalen Tageszeit.
Carolin Ector & Adrián E. Granada.
Deutsches Ärzteblatt (2025).
Perspektiven der Onkologie
Link
Featured in Cover Page
Time-of-day effects of drugs revealed by high-throughput deep phenotyping
Carolin Ector, Christoph Schmal, Jeff Didier, Sébastien De Landtsheer, Anna-Marie Finger, Francesca Müller-Marquardt, Johannes Schulte, Thomas Sauter, Ulrich Keilholz, Hanspeter Herzel, Achim Kramer, Adrián E. Granada
Nature Communications (2024).
News articles about our work
Charite Press Release
Eurekalert
Circadian period is compensated for repressor protein turnover rates in single cells
PNAS | Proceedings of the National Academy of Sciences (2024).
Circadian Coupling Orchestrates Cell Growth
Preprint Biorxiv (2024). Link
Time-of-day effects of drugs revealed by high-throughput deep phenotyping
Carolin Ector, Christoph Schmal, Jeff Didier, Sébastien De Landtsheer, Anna-Marie Finger, Francesca Müller-Marquardt, Johannes Schulte, Thomas Sauter, Ulrich Keilholz, Hanspeter Herzel, Achim Kramer, Adrián E. Granada
Preprint Biorxiv (2024). Link
p53 and p21 dynamics encode single cell DNA damage levels, fine-tuning proliferation and shaping population’s heterogeneity
Nica Gutu, Neha Binish, Ulrich Keilholz, Hanspeter Herzel, Adrián E. Granada
Communications Biology Vol. 6, 1196 (2023). Link
Analysis of complex circadian time series data using wavelets
Christoph Schmal, Gregor Mönke, Adrián E Granada.
Circadian Regulation: Methods and Protocols, 35-54, (2022). Link
Intercellular coupling between peripheral circadian oscillators by TGF-β signaling
Anna-Marie Finger, Sebastian Jäschke, Marta Del Olmo, Robert Hurwitz, Adrián E Granada, Hanspeter Herzel, Achim Kramer
Science advances 7 (30), eabg5174, (2021). Link
Live-cell imaging of circadian clock protein dynamics in CRISPR-generated knock-in cells
Christian H Gabriel, Marta Del Olmo, Amin Zehtabian, Marten Jäger, Silke Reischl, Hannah van Dijk, Carolin Ulbricht, Asylkhan Rakhymzhan, Thomas Korte, Barbara Koller, Astrid Grudziecki, Bert Maier, Andreas Herrmann, Raluca Niesner, Tomasz Zemojtel, Helge Ewers, Adrián E Granada, Hanspeter Herzel, Achim Kramer
Nature communications 12 (1), 3796, (2021). Link
Optimal time frequency analysis for biological data – pyBOAT.
Gregor Mönke, Frieda A. Sorgenfrei, Christoph Schmal, Adrián E. Granada.
Preprint biorXiv doi.org/10.1101/2020.04.29.067744 (2020). Link
PyBOAT software repository
The effects of proliferation status and cell cycle phase on the responses of single cells to chemotherapy.
Adrián E. Granada, Alba Jiménez, Jacob Stewart-Ornstein, Nils Blüthgen, Simone Reber, Ashwini Jambhekar, and Galit Lahav.
Molecular Biology of the Cell . Volume 31, Issue 8. (2020). Link
Publications Prior to the Start of the Granada Lab Research Group in 2020
Information Transfer in the Mammalian Circadian Clock.
Granada AE, Herzel H, Kramer A, Abraham U.
Information and Communication Theory in Molecular Biology. Springer (2018). Link
Tuning the phase of circadian entrainment.
Bordyugov G, Abraham U, Granada AE, Rose P, Imkeller K, Kramer A, Herzel H
Journal of the Royal Society Interface. 6;12(108), (2015). Link
Genetic redundancy strengthens the circadian clock leading to a narrow entrainment range
Erzberger A, Hampp G, Granada AE, Albrecht U, Herzel H.
Journal of the Royal Society Interface 10(84):20130221, (2013). Link
How Coupling Determines the Entrainment of Circadian Clocks.
Bordyugov G*, Granada AE*, and Herzel H.
European Physical Journal B, (2011). Link
Circadian desynchronization.
Granada AE, Cambras T, Diez-Noguera A, Herzel H.
Journal of the Royal Society Interface 1:153-166, (2011). Link
Transients and bifurcations of the mammalian circadian system: From synchronization to desynchronization mechanisms
Granada AE.
Logos-Verlag. ISBN-13: 978-3-8325-2966-6, (2011). Link
Coupling governs entrainment range of circadian clocks.
Abraham U*, Granada AE*, Westermark PO*, Heine M*, Kramer A, and Herzel H
Molecular Systems Biology, 6:438, (2010). Link
How to achieve fast entrainment? The timescale to synchronization.
Granada AE, Herzel H (2009)
PLoS One 4: e7057, (2009). Link
Phase response curves elucidating the dynamics of coupled oscillators.
Granada AE, Hennig RM, Ronacher B, Kramer A, Herzel H
Methods in Enzymology 454:1–27, (2009). Link
The generation of respiratory rhythms in birds
Granada AE, Gabitto M, García G, Alliende J, Méndez J, Trevisan M, Mindlin GB.
Physica A. 371:84–87, (2006). Link